Talos automates rare disease reanalysis, limiting review to 1.3 variants per patient
Talos re‑examines stored genomic data as knowledge evolves, recovering 90 % of diagnosable cases while surfacing only 1.3 candidate variants per patient. In a cohort of ~5,000 undiagnosed patients it added 241 new diagnoses—5 % extra yield—with analysts reviewing just one new variant per 200 patients. This makes systematic, frequent reanalysis sustainable at scale.